Hemolysis with alloxan and alloxan-like compounds, and the protective action of tocopherol.
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چکیده
منابع مشابه
Diabetes-Induced Damages in Rat Kidney and Brain and Protective Effects of Natural Antioxidants
Context: In case of diabetes, persistent and chronic hyperglycaemia may generate free radicals and reactive oxygen species (ROS), which trigger an oxidative stress. Garlic (Allium sativum) is a rich source of bioactive compounds and is used in folk medicine for the treatment of various diseases, including diabetes. Besides, α-tocopherol and magnesium have been shown to possess antioxidative pro...
متن کاملAlloxan-like action of some SH-inhibitors on glucose tolerance in rabbits.
SYNOPSIS This report was designed to grasp exactly the action of alloxan by the true tolerance test reported by Takeuchi (1961). The action of alloxan is manifested in two different ways depending on the dose; e-k decreased in a smaller dose and increased in a larger dose. The former is named mesoxalic acid-like action and the latter alloxan-like action. The effect of the compounds related with...
متن کاملSulfhydryl protection against dehydroascorbic acid diabetes.
Dehydroascorbic acid has been shown to produce diabetes (1, 2). In this respect it is similar to alloxan (3). Whereas alloxan has not yet been shown to occur physiologically, dehydroascorbic acid is accepted as occurring under physiological conditions in the cells of animals (4). Therefore, it is important to study the factors that are known to affect alloxan diabetes in order to determine thei...
متن کاملReactions of alloxan and dialuric acid with the sulfhydryl group.
It was the purpose of this investigation to study the reaction between alloxan and the sulfhydryl group of cysteine and compounds containing cysteine. Alloxan injected into animals produced diabetes (1). Cysteine or glutathione injected prior to alloxan, but not after alloxan, protected animals from diabetes (2). On the basis of these data it was postulated that alloxan produced diabetes by the...
متن کاملThe Protective Effects of Allium Saralicum Aqueous Extract on Blood Glucose and Some Related Biochemical Factors in Alloxan-Induced Diabetic Male Rats: An Experimental Study
Background and Objectives: Diabetes is one of the most common metabolic disorders. Medicinal plants have been used for controlling diabetes. The aim of the present study was to investigate the protective effect of Allium saralicum on blood glucose and some related biochemical factors in alloxan induced type-1 diabetes in male rats. Materials and Methods: In this experimental study, diabetes w...
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عنوان ژورنال:
- Blood
دوره 5 11 شماره
صفحات -
تاریخ انتشار 1950